Research progress on the association between radiation-induced lung injury and ferroptosis
10.3760/cma.j.cn113030-20200506-00231
- VernacularTitle:放射性肺损伤与铁死亡相关性研究进展
- Author:
Yuming ZHENG
;
Mawei JIANG
;
Leizhen ZHENG
;
Meiling ZHU
- From:
Chinese Journal of Radiation Oncology
2021;30(5):527-530
- CountryChina
- Language:Chinese
-
Abstract:
Radiation-induced lung injury (RILI) is a common complication after radiotherapy for lung cancer and alternative thoracic malignant tumors, while ferroptosis is a regulated cell death triggered by iron-dependent membrane lipid peroxidation. In this article, the relationship between RILI and ferroptosis was investigated from oxidative damage induced by reactive oxygen species, antioxidant network and iron homeostasis regulated by nuclear factor erythroid 2-related factor 2(Nrf2) as well as transforming growth factor involved in the inflammatory response, aiming to mitigate or inhibit the occurrence of RILI through regulating ferroptosis, thereby improving clinical prognosis of patients undergoing radiotherapy.
