Allopurinol Induced Abnormalities of Liver Function Test in Gout Patients.
- Author:
Gi Hyeon SEO
;
Hong Joon AHN
;
Hoon Suk CHA
;
Jin Seok KIM
;
Kwang Cheol KOH
;
Eun Mi KOH
- Publication Type:Original Article
- Keywords:
Allopurinol;
Gout;
Hepatotoxicity;
Liver function test
- MeSH:
Allopurinol*;
Follow-Up Studies;
Gout*;
Humans;
Liver Function Tests*;
Liver*
- From:The Journal of the Korean Rheumatism Association
1999;6(1):62-68
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Liver function tests before treatment showed abnormalities of liver function tests during treatment, while 15(68. 2%) of 22 patients who had abnormal liver function tests before treatment showed abnormalities during treatment. In 12 of the 25 patients who showed abnormalities of liver function tests during treatment with allopurinol, allopurinol was stopped and all patients showed improvement of liver function tests. In remaining 13 patients, 10 patients were improved and other 2 patients showed only mild abnormalities of liver function tests despite of continuing allopurinol and 1 patient was lost during follow-up. CONCLUSION: Abnormalities of liver function tests were common during treatment with allopurinol. Most patiensts who had mild abnormalities of liver functions tests during treatment with allopurinol were improved regardless of continuing allopurinol.
