Research progress on radiosensitivity-related genes and biomarkers in esophageal carcinoma
10.3760/cma.j.cn113030-20200526-00276
- VernacularTitle:食管癌放射敏感性相关基因及分子标志物研究进展
- Author:
Xiaofeng WANG
;
Jun LIANG
- From:
Chinese Journal of Radiation Oncology
2021;30(4):419-423
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy is one of the most important treatment methods for esophageal carcinoma. However, radiation resistance is the biggest problem and obstacle for patients with esophageal carcinoma treated with radiotherapy. Radiosensitivity is the focus and difficulty in the study of tumor radiobiology. A variety of genes and their expression products affect the radiosensitivity of esophageal carcinoma. Consequently, if the genes and biomarkers that determine radiosensitivity can be detected before radiotherapy, it will play a vital role in investigating the mechanism of radiotherapy sensitization, targeted therapy and radiotherapy efficacy prediction to guide individual therapy. In this article, major genes and biomarkers associated with esophageal carcinoma radiosensitivity in recent years were reviewed from different signal transduction pathways.
