Study of related factors of radiation-induced hypothyroidism in nasopharyngeal carcinoma

Ling Zhou; Jia Chen; Shuang Huang; Changjuan Tao; Wei Shen; Ming Chen; Zhonghua YU; Yuanyuan Chen

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Study of related factors of radiation-induced hypothyroidism in nasopharyngeal carcinoma

VernacularTitle:鼻咽癌放射性甲状腺功能减退的相关因素研究
Author: Ling ZHOU ; Jia CHEN ; Shuang HUANG ; Changjuan TAO ; Wei SHEN ; Ming CHEN ; Zhonghua YU ; Yuanyuan CHEN
From: Chinese Journal of Radiation Oncology 2021;30(1):11-15
CountryChina
Language:Chinese
Abstract: Objective:To explore the main factors of hypothyroidism after radiotherapy and to identify the optimal thyroid dosimetric parameters by analyzing the dosimetric parameters of the thyroid.Methods:The general clinical characteristics and dosimetric parameters of 206 patients with nasopharyngeal carcinoma treated in Cancer Hospital of University of Chinese Academy of Sciences were collected, and the correlation between them and the incidence of hypothyroidism was analyzed.Results:The incidence of hypothyroidism in patients with nasopharyngeal carcinoma after radiotherapy was 50.49%(104/206). Univariate analysis showed that gender, N-stage, volume, mean dose, V 20Gy, V 25Gy, V 30Gy, V 35Gy, V 40Gy, V 45Gy of thyroid were associated with the incidence of hypothyroidism. Multivariate analysis demonstrated that volume (≤12.82 cm 3) and mean dose of thyroid were the independent risk factors of hypothyroidism. Mean dose of thyroid combined with volume could significantly predict the incidence of hypothyroidism after radiotherapy. Conclusion:Mean dose of thyroid ≤ 47.21 Gy is the optimal dosimetric parameter for radiation-induced hypothyroidism, especially the patients with thyroid volume ≤ 12.82 cm 3 should pay more attention to the protection of thyroid gland during radiotherapy.