Dermatofibrosarcoma Protuberans: a Systematic Evaluation and Meta-analysis of Efficacy of Postoperative Radiotherapy
10.3760/cma.j.cn113030-20190805-00313
- VernacularTitle:隆突性皮肤纤维肉瘤术后放疗有效性系统评价和 Meta分析
- Author:
Anqi LYU
;
Zheng YIN
;
Shijun SHAN
;
Liangxi XIE
;
Qiying WANG
- From:
Chinese Journal of Radiation Oncology
2021;30(1):71-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy of postoperative radiotherapy (PRT) for dermatofibrosarcoma protuberans (DFSP).Methods:A systematic review and meta-analysis of articles published before February 23, 2019 were conducted. A total of 655 studies were retrieved consisting of 195 DFSP patients. Among them, 50 cases were assigned into the PRT group and 145 cases in the surgery alone (SA) group. The recurrence rate was statistically compared between two group.Results:Meta-analysis showed that the recurrence rate in the PRT group was significantly lower than that in the SA group (8% vs. 24.1%, OR=0.28, P=0.010). The recurrence rate of patients with positive margins in the PRT group was significantly lower compared with that in the SA group (8% vs. 61.5%, P=0.002). The recurrence rate of patients with negative margins in the PRT group had a decreasing trend than that in the SA group (6% vs. 21.6%, P=0.205). Conclusions:The recurrence rate of surgery combined with PRT is lower than that of SA. The recurrence rate of patients with positive margins is higher than that of those with negative margins. For patients with positive margins, PRT can decrease the recurrence rate. The recurrence rate trends to decline in patients with negative margins after receiving PRT.
