Research progress of RNA m 6A modification in malignant tumor and its mechanism of radiotherapy

VernacularTitle:RNA的m 6A修饰在恶性肿瘤及其放疗中作用机制的研究进展
Author: Junxuan YI ; Rui WANG ; Xinfeng WEI ; Mingwei WANG ; Shunzi JIN
From: Chinese Journal of Radiological Medicine and Protection 2021;41(3):234-240
CountryChina
Language:Chinese
Abstract: N 6-methyladenosine (m 6A) is the most abundant RNA base modification in mammals, especially in eukaryotic messenger RNA (mRNA). N 6-methyladenosine modification can regulate RNA splicing, translocation, stability and ultimately affect protein synthesis. m 6A modification is catalyzed by RNA writers, reduced by erasers and also be recognized by readers. Abnormal changes ofm 6A levels are closely related to tumor occurrence and development, including proliferation, growth, invasion and metastasis. In the process of tumor radiotherapy, m 6A modification affects the efficacy of radiotherapy by affecting DNA damage, tumor stem cell generation and tumor cell radiation sensitivity. This article reviews the role of m 6A-modified epigenetic regulation in malignant tumors and the research progress of its mechanism in tumor radiotherapy, in order to provide new ideas for the development of clinical tumor molecular targeted therapies and radiosensitizers.