Hyperhomocysteinemia, a Biochemical Tool for Differentiating Ischemic and Nonischemic Central Retinal Vein Occlusion during the Early Acute Phase.
- Author:
Kapil Deb LAHIRI
1
;
Somnath MUKHERJEE
;
Sambuddha GHOSH
;
Suman MUKHERJEE
;
Jayanta DUTTA
;
Himadri DATTA
;
Harendra Nath DAS
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Central retinal vein occlusion; Homocysteine; Hyperhomocysteinemia; Ischemic central retinal vein occlusion; Nonischemic central retinal vein occlusion
- MeSH: Acute Disease; Aged; Biomarkers/*blood; Case-Control Studies; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Hyperhomocysteinemia/blood/*complications/diagnosis; Male; Middle Aged; Prospective Studies; Retinal Vein Occlusion/complications/*diagnosis; Time Factors
- From:Korean Journal of Ophthalmology 2015;29(2):86-91
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: The purpose of the study was to differentiate ischemic central retinal vein occlusion (CRVO) from nonischemic CRVO during the early acute phase using plasma homocysteine as a biochemical marker. METHODS: Fasting plasma homocysteine, serum vitamin B12, and folate levels were measured in 108 consecutive unilateral elderly adult (age >50 years) ischemic CRVO patients in the absence of local and systemic disease and compared with a total of 144 age and sex matched nonischemic CRVO patients and 120 age and sex matched healthy control subjects. RESULTS: Homocysteine level was significantly increased in the patients with ischemic CRVO in comparison with nonischemic CRVO patients (p = 0.009) and also in comparison with control subjects (p < 0.001). Analysis also showed that hyperhomocysteinemia was associated with increased incidence of ischemic CRVO (odds ratio, 18) than that for nonischemic CRVO (odds ratio, 4.5). Serum vitamin B12 and folate levels were significantly lower (p < 0.001) in CRVO patients compared to the control but were not significantly different between nonischemic and ischemic CRVO patients (p > 0.1). CONCLUSIONS: Hyperhomocysteinemia can be regarded as useful in differentiating nonischemic and ischemic CRVO during the early acute phase in absence of local and systemic disease in the elderly adult (age >50 years) population.
