Amide proton transfer-weighted MRI of cervical squamous carcinoma: correlation with Ki-67 proliferation status
10.3760/cma.j.cn112149-20200415-00561
- VernacularTitle:宫颈鳞癌酰胺质子转移加权成像与Ki-67表达的相关性研究
- Author:
Yonglan HE
;
Chengyu LIN
;
Yafei QI
;
Xiaoqi WANG
;
Hailong ZHOU
;
Yuan LI
;
Bo CHEN
;
Yang XIANG
;
Huadan XUE
;
Zhengyu JIN
- From:
Chinese Journal of Radiology
2021;55(5):517-521
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between amide proton transfer-weighted (APTw) values and Ki-67 labeling index of cervical squamous cell carcinoma.Methods:From October 2017 to December 2018, 24 patients with cervical squamous cell carcinoma [International Federation of Gynecology and Obstetrics (FIGO) stage Ⅰ-Ⅲ] were prospectively enrolled in Peking Union Medical College Hospital and underwent pelvic morphological MRI on a 3.0 T MR scanner, including three-dimensional turbo-spin-echo APTw imaging and DWI. The maximum diameters of the lesions, APTw values and ADC values on the slice with the maximum diameter of the lesion were independently measured by two radiologists. The ICC was computed to evaluate the inter-observer consistency. Ki-67 immunohistochemical expression status was assessed by one pathologist. The Pearson correlation analysis was performed between the APTw values, maximum diameters, ADC values and Ki-67 labeling index.Results:The APTw values of cervical squamous cell carcinoma were (2.9±0.5)%. Inter-observer ICC was 0.972 (95%CI 0.937-0.988). The APTw values were positively moderately correlated with Ki-67 labeling index [(61.9±18.7)%, r=0.532, P=0.008]. The maximum diameters of the lesions were (28.7±10.6) mm. The mean ADC values were (0.998±0.217)×10 -3 mm 2/s. No correlations were found between maximum diameters, ADC values and Ki-67 labeling index ( r=0.038, P=0.859; r=0.238, P=0.263). Conclusion:APTw values can partially reveal the proliferation status of cervical squamous cell carcinoma.
