The Wound Healing Effects of AmniSite-Lens in Rabbits.
10.3341/jkos.2013.54.2.338
- Author:
Tae Hyung KIM
1
;
Yeoun Sook CHUN
;
Jae Chan KIM
Author Information
1. Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea. jck50ey@kornet.net
- Publication Type:Original Article
- Keywords:
Amniotic membrane;
Amniotic membrane contact lens;
AmniSite-Lens;
Chemical burn;
Wound healing
- MeSH:
Amnion;
Bandages;
Burns;
Burns, Chemical;
Cornea;
Corneal Opacity;
Rabbits;
Wound Healing
- From:Journal of the Korean Ophthalmological Society
2013;54(2):338-345
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The effects of AmniSite-Lens on wound healing were evaluated for a burn wound on a rabbit cornea. METHODS: A chemical burn was inflicted on the cornea of rabbits using 0.1N NaOH and a superficial keratectomy with trephine was performed. The control group consisted of rabbits with a bandage contact lens (Focus Lens) after the operation. In the other group, the AmniSite-Le was applied on the rabbits' cornea. The rabbits were evaluated for the following: 1) the time of epithelialization; 2) the grade of corneal opacity; and 3) the histological analysis by evaluation of inflammatory reaction and apoptotic keratocytes. RESULTS: In the alkali-burn model, the time of epithelialization in the AmniSite-Lens group was not statistically significant compared with the bandage contact lens group. There was no difference of corneal opacity at postoperative week 1. The corneal opacity in the AmniSite-Lens group was clearer than the bandage contact lens group at postoperative weeks 4 and 8 and the difference of corneal opacity was statistically significant. In the keratectomy model, the time of epithelialization in the AmniSite-Lens group was not statistically significant compared with the bandage contact lens group. The corneal opacity in the AmniSite-Lens group was clearer than the bandage contact lens group at postoperative weeks 1 and 4 and the difference of corneal opacity was statistically significant. CONCLUSIONS: The AmniSite-Lens has both the wound healing effect of an amniotic membrane and the convenience of a bandage contact lens.
