Research progress of miRNA27a in malignant tumor diseases

VernacularTitle:miRNA27a在恶性肿瘤疾病中的研究进展
Author: Huan LI ; Wenhua TAN
From: Journal of Chinese Physician 2021;23(5):797-800
CountryChina
Language:Chinese
Abstract: MicroRNAs (miRNAs) are a class of non coding small RNAs. MiRNAs can regulate cell signal transduction and gene expression, affect cell proliferation, apoptosis and other cell physiological processes, and play a crucial role in maintaining normal biological metabolism and homeostasis of the intracellular environment. In addition, miRNAs are widely involved in the occurrence and progress of cancer. Studies have shown that miRNA27a, a member of the miRNAs family, can play the role of oncogene or tumor suppressor gene in different cancer disease models. This article will review the expression, mechanism and potential clinical application of miRNA27a in different malignant tumors.