Research progress on the relationship between LINC01018-E2F1-CDK6 and malignant tumor

VernacularTitle:LINC01018-E2F1-CDK6与恶性肿瘤关系的研究进展
Author: Hongwei CHEN ; Jiahong CAI ; Jie CHEN ; Du CHEN ; Liang JIANG ; Lizhi ZHOU ; Zhoujing LIU
From: Journal of Chinese Physician 2021;23(4):634-636
CountryChina
Language:Chinese
Abstract: It is known that LINC01018 and CDK6 are associated with the occurrence, progression and recurrence of malignant tumor. Our preliminary data showed that the expression of LINC01018 was down-regulated and that of CDK6 was up-regulated, which were related with the malignancy grade. Bioinformatics suggested that E2F1 binding site exist in the CDK6 promoter region, and LINC01018 might interact with E2F1. Thus we speculate that the expression of LINC01018 in malignant tumor is decreased. The interaction between LINC01018 and E2F1 activates E2F1, promotes the transcription activation of CDK6, and affects tumor proliferation, invasion and metastasis. All these are expected to reveal the effect and mechanisms of LINC01018 in the development and regulation of malignant tumor, and provide new ideas and evidences for its treatment.