The biological characteristics of FGF23 and its relationship with metabolic diseases

VernacularTitle:FGF23生物学特征及其与代谢性疾病关系的研究
Author: Rong CHEN ; Hong LIU ; Zhifeng SHENG
From: Journal of Chinese Physician 2021;23(3):465-470
CountryChina
Language:Chinese
Abstract: Fibroblast growth factor 23 (FGF23) is a new endocrine factor, mainly expressed in osteoblasts and osteoblasts. Many studies have found that FGF23 can act on kidney, parathyroid and other tissues after binding with Klotho protein, and participate in bone mineral metabolism. In addition, in recent years, the role of FGF23 in exoskeleton has been gradually discovered, such as FGF23 and thyroid diseases, diabetes and so on. Therefore, understanding the biological characteristics, regulatory mechanism of FGF23 and its relationship with related diseases is of great clinical significance for the diagnosis and treatment of diseases. This article reviews the relationship between FGF23 and metabolic diseases such as phosphorus metabolic disease, parathyroid disease, hyperthyroidism, osteoporosis, diabetes, iron metabolism and so on.