Research progress of non-coding RNA in doxorubicin-induced cardiotoxicity

VernacularTitle:非编码RNA在阿霉素心脏毒性中的研究进展
Author: Wenqiang LU ; Jufang CHI ; Hangyuan GUO
From: Journal of Chinese Physician 2021;23(2):310-313
CountryChina
Language:Chinese
Abstract: Doxorubicin is an effective anthracycline chemotherapeutic drug, which is widely used in single or combined chemotherapy for various malignant tumors. However, the cardiotoxicity caused by doxorubicin has limited its clinical application. Despite a large amount of research investment, no suitable target has been found to reduce cardiotoxicity caused by doxorubicin while guaranteeing the effect of chemotherapy. Recent studies have found that non-coding RNA is related to doxorubicin-induced cardiomyopathy. Further explaining the relationship between the two may provide new strategies for the diagnosis, prevention and treatment of doxorubicin-induced cardiotoxicity.