Progress in the pathogenesis of cholestasis during the early stage of sepsis
10.3760/cma.j.cn121430-20201109-00707
- VernacularTitle:脓毒症早期胆汁淤积发生机制的研究进展
- Author:
Liangsheng TANG
;
Zhaohui TANG
- From:
Chinese Critical Care Medicine
2021;33(4):506-508
- CountryChina
- Language:Chinese
-
Abstract:
The effects of sepsis on the liver include hypoxic hepatitis caused by ischemia and shock, liver cell damage caused by excessive inflammation, and cholestasis caused by changes in bile metabolism. Among them, cholestasis is a common complication in patients with sepsis. Cholestasis and jaundice in patients with sepsis are associated with an increased risk of infection, leading to an increased mortality rate. So far, the exact mechanism of sepsis with cholestasis is still unclear, so this article briefly reviews the mechanism of cholestasis during the early stage of sepsis.