Research progress on exosome-mediated immune regulation of acute lung injury

VernacularTitle:外泌体介导急性肺损伤免疫调节的研究进展
Author: Jiaqi LI ; Mingzhuo LIU ; Yong HU ; Guanghua GUO
From: Chinese Critical Care Medicine 2021;33(1):118-121
CountryChina
Language:Chinese
Abstract: Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a respiratory disorder with high morbidity and mortality caused by various causes. Exosomes can mediate cell communication through paracrine pathways, transfer proteins, lipids, nucleic acids, etc., and interfere with the biological functions of recipient cells. Various cell-derived exosomes have been reported to play an immunomodulatory role in the ALI/ARDS inflammatory model. This article reviews the mechanism of exosomes involved in immune regulation of ALI/ARDS and possible therapeutic approaches.