Curative effects of early continuous blood purification therapy on moderate to severe acute pancreatitis in 47 patients
10.3760/cma.j.issn.1008-6706.2021.05.019
- VernacularTitle:早期连续性血液净化治疗中重度急性胰腺炎47例疗效分析
- Author:
Shumin TU
- From:
Chinese Journal of Primary Medicine and Pharmacy
2021;28(5):728-732
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the curative effects of early continuous blood purification therapy on moderate to severe acute pancreatitis.Methods:The clinical data of 94 patients with moderate to severe acute pancreatitis who received treatment in the First People's Hospital of Shangqiu, China between January 2018 and October 2019 were retrospectively analyzed. These patients were divided into a control group and an observation group ( n =47/group) according to different treatment methods. The control group was treated with conventional treatment, while the observation group was treated with continuous blood purification therapy based on conventional treatment. The time to abdominal pain and distension relief, the changes of vital signs such as respiration and heart rate, renal function, the levels of liver enzymes, C-reactive protein and interleukin-6, median remission time of systemic inflammatory response syndrome, the Acute Physiology, Age, Chronic Health Evaluation II score, modified Marshall score, and modified CT severity index (MCTSI) were compared between the two groups. Results:The time to abdominal pain relief [(2.28 ± 0.44) d] and the median remission time of systemic inflammatory syndrome [(5.27 ± 0.95) d] were significantly shorter than those in the control group [(6.23 ± 1.01) d and (11.30 ± 1.12) d, t = 34.213 and 28.308, both P < 0.05]. The levels of alanine aminotransferase, blood urea nitrogen, serum creatinine, C-reactive protein and interleukin-6 in the observation group were (28.22 ± 34.38) U/L, (5.73 ± 1.83) mmol/L, (70.26 ± 4.34) μmol/L, (102.66 ± 3.29) mg/L, (110.45 ± 5.50) pg/L respectively, which were significantly lower than those in the control group [(47.26 ± 56.61) U/L, (10.55 ± 3.09) mmol/L, (114.21 ± 6.87) μmol/L, (210.51 ± 10.11) mg/L, (281.77 ± 14.99) pg/L, t = 3.520, 23.724, 81.266, 96.618, 114.005, all P < 0.05]. The Acute Physiology, Age, Chronic Health Evaluation II score, modified Marshall score, and modified CT severity index in the observation group were (11.43 ± 0.66) points, (3.06 ± 0.29) points, (8.16 ± 0.27) points, which were significantly lower than (18.49 ± 1.77) points, (4.92 ± 0.37) points, (9.57 ± 0.35) points respectively in the control group ( t = 39.590, 76.458, 67.484, all P < 0.05). Conclusion:Continuous blood purification therapy can effectively remove metabolites and poisons from the body, shorten the duration of systemic inflammatory response syndrome, promote the recovery of body function, and thereby improve the prognosis of moderate to severe acute pancreatitis.
