Research progress of TGF-β/Smad signaling pathway in osteoarthritis

VernacularTitle:TGF-β/Smad信号通路在骨关节炎中作用的研究进展
Author: Jing MA ; Ning ZOU
From: Chinese Journal of Endemiology 2021;40(3):253-258
CountryChina
Language:Chinese
Abstract: Osteoarthritis (OA) is a bone and joint disease caused by multiple factors, which seriously threatens human health. It is mainly manifested as joint pain and dysfunction. In severe cases, it can cause deformity. The mechanism of OA is not very clear, and there is a lack of effective therapeutic drugs; the exploration of etiology, pathogenesis and preventive measures of OA has always been an important research direction in this field. Studies have found that the transforming growth factor-β (TGF-β)/Smad signaling pathway plays a key role in the occurrence and development of OA. This article reviews the research progress of TGF-β/Smad signaling pathway in OA in recent years at home and abroad.