Research progress on the mechanism of liver injury induced by arsenic
10.3760/cma.j.cn231583-20200905-00234
- VernacularTitle:砷致肝损伤作用机制的研究进展
- Author:
Wenjing MA
;
Man LYU
;
Jie YANG
;
Kewei WANG
- From:
Chinese Journal of Endemiology
2021;40(1):75-80
- CountryChina
- Language:Chinese
-
Abstract:
Arsenic is a carcinogenic metal-like poison that is widely present in the natural environment. Acute or long-term exposure to arsenic can cause a series of liver injury, such as hepatomegaly, liver fibrosis, cirrhosis, and even liver cancer. In recent years, new progress has been made in the study of the mechanism of arsenic exposure on liver injury. This article will systematically review the main pathogenesis of arsenic-induced liver injury, mainly covering DNA methylation, oxidative stress, inflammatory response, hepatocyte apoptosis, liver fibrosis and autophagy. It aims to provide a theoretical reference for the prevention and treatment of arsenic poisoning.
