Graft-Versus-Host Disease Limited to the Irradiated Skin.
10.5021/ad.1993.5.2.125
- Author:
Young Min PARK
;
Soo Byung CHOI
;
Jong Yuk YI
;
Baik Kee CHO
;
Won HOUH
;
Choon Choo KIM
- Publication Type:Case Report
- Keywords:
Graft-verus-host disease;
Irradiation
- MeSH:
Dermis;
Diarrhea;
Epidermis;
Exanthema;
Graft Rejection;
Graft vs Host Disease*;
HLA-DR Antigens;
Humans;
Keratinocytes;
Liver Diseases;
Lymphocytes;
Skin*
- From:Annals of Dermatology
1993;5(2):125-129
- CountryRepublic of Korea
- Language:English
-
Abstract:
We present two very interesting cases of acute graft-versus-host disease (GVHD), whose skin rashes initially appeared on the localized area of total nodal irradiation (TNI) performed previously to prevent graft rejection and/or GVHD. The histopathologic findings showed some dyskeratotic cells in the epidermis and perivascular mononuclear cell infiltration in the upper dermis. The immunohistochemical studies revealed that HLA-DR was diffusely strongly positive in a number of keratinocytes, whereas both CD4 and CD8 were focally weakly positive in the perivascular lymphocytes in the upper dermis. Later on, liver dysfunction and diarrhea developed and skin rashes began to spread over the other parts of the body in those two patients.
