Study on masticatory function and expression of monocyte chemoattractant protein-1 and tumor necrosis factor-αin gingival crevicular fluid of patients with dentition loss after dental implant repair
10.3760/cma.j.cn115455-20200403-00413
- VernacularTitle:口腔种植修复对牙列缺失患者咀嚼功能及龈沟液单核细胞趋化蛋白-1和肿瘤坏死因子-α表达的影响
- Author:
Renjie FU
;
Jiangwei YAO
;
Jiaqing SUN
- From:
Chinese Journal of Postgraduates of Medicine
2021;44(4):353-356
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the masticatory function and the expression of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α(TNF-α) in gingival crevicular fluid.Methods:The clinical data of 98 patients with dentition loss admitted to Tongxiang First People′s Hospital from June 2017 to June 2019 were analyzed, and 49 cases were treated with oral implant repair(observation group) and 49 cases were treated with conventional repair(control group). Both groups were followed up for 6 months. The masticatory function, speech function, retention function, quality of life and the changes of MCP-1 and TNF-α in gingival crevicular fluid were compared before treatment and 6 months after treatment.Results:The total effective rate of the observation group was higher than that of the control group: 95.92%(47/49) vs. 79.59%(39/49), and the difference was statistically significant ( χ2=6.078, P<0.05). At 6 months after treatment, the scores of masticatory function, speech function and retention function in the observation group were higher than those in the control group ( P<0.05). The scores of emotional function, social function and physiological function in the observation group were higher than those in the control group ( P<0.05). The levels of MCP-1 and TNF-α in gingival crevicular fluid of the observation group were lower than those of the control group: (32.09 ± 7.65) μg/L vs. (43.62 ± 9.23) μg/L, (2.19 ± 0.38) μg/L vs. (3.20 ± 0.51) μg/L, and the differences were statistically significant ( P<0.05). Conclusions:Dental implant repair is effective for patients with dentition loss, and it can improve masticatory function and quality of life, and reduce the expression of MCP-1 and TNF-α in gingival crevicular fluid.
