Application of proteomics in age-related macular degeneration
10.3760/cma.j.cn115989-2019-0105-00006
- VernacularTitle:蛋白质组学分析在年龄相关性黄斑变性研究中的应用
- Author:
Fan YANG
;
Xiaodong SUN
- From:
Chinese Journal of Experimental Ophthalmology
2021;39(1):72-77
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration (AMD) is the mainirreversible blinding eye disease in the elderly.Its main pathogenic factors include age, genetic variation and lifestyle, but the specific pathogenesis has not been fully elucidated.As an emerging research method, proteomics technology has been gradually applied in the field of ophthalmology in recent years.A large number of studies about proteomic analysis of blood, tears, aqueous humor, vitreous humor, retina and choroid, drusen and RPE cell samples from AMD patients have been carried out to screen AMD biomarkers and explore the mechanism of AMD.These results can not only help us to make a more accurate diagnosis of AMD, but also play a guiding role in the selection of treatment targets and prognosis.
