Vascular endothelial growth factor in acute lung iujury and acute respiratory distress syndrome
10.3760/cma.j.issn.1673-4912.2021.05.018
- VernacularTitle:血管内皮生长因子在急性肺损伤和急性呼吸窘迫综合征中的研究进展
- Author:
Xiaoting PENG
;
Qiuping LI
- From:
Chinese Pediatric Emergency Medicine
2021;28(5):424-428
- CountryChina
- Language:Chinese
-
Abstract:
Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS)is one of the most common clinical critical illnesses in ICU.The basic pathological features of this disease are uncontrolled inflammation, destruction of the alveolar-capillary barrier and diffuse alveolar and interstitial edema.In severe cases, patients may develop significant pulmonary fibrosis.Based on the pathological changes, repairing damaged alveolar-capillary membrane and reducing fibrosis seem to be the key to the treatments of ALI/ARDS.Vascular endothelial growth factor(VEGF) is known to be the main regulator of endothelial cell proliferation and differentiation.Previous studies have suggested that VEGF plays an important role in the inflammatory reactions and pathological manifestations of ALI/ARDS, but the results are complex.This review mainly focused on the expression changes of VEGF in ALI/ ARDS and the effects and mechanisms of regulating VEGF signaling.
