Research progress of platelets in sepsis
10.3760/cma.j.issn.1673-4912.2021.02.014
- VernacularTitle:血小板在脓毒症中的研究进展
- Author:
Qiushan CHEN
;
Xingyong WANG
- From:
Chinese Pediatric Emergency Medicine
2021;28(2):145-147
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is an inflammatory response syndrome caused by systemic immune disorders caused by infection.Platelets play an important role in the development of sepsis.Platelets can react with pathogenic microorganisms through adhesion, aggregation, activation, threshing, and have achieved the role of protecting in the body.At the same time, during sepsis, platelets can also interact with immune cells such as neutrophils and participate in formation of microthrombi and inflammation.Therefore, platelets have an antimicrobial effect and cooperate with other innate immune cells to form a complex intravascular immune defense system to prevent the spread of bacteria.However, if the internal immune function mediated by it is dysregulated, the host cells and tissues may be seriously collaterally damaged, resulting in sepsis-related organ dysfunction.This article reviewed the research progress of platelet immune mechanism and organ dysfunction in sepsis.
