The usage of intravenous immunoglobulin in neonatal infection
10.3760/cma.j.issn.1673-4912.2021.02.004
- VernacularTitle:静脉注射人免疫球蛋白在新生儿感染性疾病中的应用
- Author:
Yongyan SHI
;
Jianhua FU
- From:
Chinese Pediatric Emergency Medicine
2021;28(2):98-101
- CountryChina
- Language:Chinese
-
Abstract:
Intravenous immunoglobulin(IVIG) contains multiple-antigen-specific IgGs and may protect the host from a wide spectrum of pathogens including but not limited to virus and bacteria.With a low IgG level, neonates, especially preterm infants are prone to infection.IVIG can rapidly increase the concentration of serum IgG level, and enhance the anti-infectious and immune-regulatory functions.It has been widely used as a common treatment against neonatal infections.However, there has been inadequate evidence to support the routine usage of IVIG.While prolonged IVIG usage may be beneficial to the extremely or very low birth weight with sepsis, the prophylactic usage of IVIG to decrease the risk of late-onset sepsis in preterm infants depends on the situation of nosocomial infections in different NICUs and the cost-effect efficiency.
