Diagnosis of angiostrongylus eosinophilic meningitis in infants by high-throughput sequencing: 2 cases of reports

VernacularTitle:高通量测序技术诊断婴幼儿广州管圆线虫嗜酸性脑膜脑炎2例
Author: Hong CHEN ; Xin DING ; Yu DAI ; Xueyan CAO ; Huafang ZOU ; Jianxiang LIAO ; Dezhi CAO
From: Chinese Journal of Applied Clinical Pediatrics 2021;36(10):781-783
CountryChina
Language:Chinese
Abstract: Infants suffering from angiostrongylus eosinophilic meningitis (AEM) is rare, while AEM can cause severe consequences.The diagnostic value of high-throughput sequencing for AEM was studied by analyzing 2 AEM children (< 2 years old) in the Department of Neurology, Shenzhen Children′s Hospital in 2019.Case 1 mainly pre-sented intermittent fever, vomiting, mental fatigue and bregma bulge.Case 2 mainly manifested intermittent fever, cough, vomiting and convulsion.Due to hypereosinophils in patients′ peripheral blood and cerebrospinal fluid (CSF), and abundant DNA sequences from a cantonensis in CSF and positive antibody test, the patients were diagnosed with AEM.The patients were treated with albendazole to deworm, and small doses of methylprednisolone to reduce inflammation.The clinical characteristics of AEM infant are not typical, and high-throughput sequencing technology can assist the diagnosis of AEM.