Research progress on the relationship between pentraxin 3 and Henoch-Schonlein purpura

VernacularTitle:血浆正五聚蛋白3与过敏性紫癜关系的研究进展
Author: Lu LIU ; Yongqiang ZHOU ; Zhongbin TAO ; Yuning LI
From: Chinese Journal of Applied Clinical Pediatrics 2021;36(9):714-717
CountryChina
Language:Chinese
Abstract: Henoch-Schonlein purpura (HSP) is one of the most common clinical manifestations of systemic small vasculitis in children with non-thrombocytopenic, and mainly manifested as skin purpura, arthritis, gastrointestinal symptoms and Henoch-Schonlein purpura nephritis (HSPN). The severity of renal involvement is the main factor determining the long-term prognosis of children with HSP.Studies have revealed that the determination of pentraxin 3 (PTX3) in serum can be used for early diagnosis of HSPN and prediction of renal injury.In this paper, the origin, gene and protein structure, function, potential relationship and mechanism of action between PTX3 and HSP were discussed, so as to provide new ideas for the early diagnosis and treatment of HSPN.