Clinical analysis of two pediatric precursor B-cell acute lymphoblastic leukemia with C-MYC rearrangement
10.3760/cma.j.cn101070-20200318-00445
- VernacularTitle:伴 C-MYC重排的儿童急性前B淋巴细胞白血病2例临床特征研究
- Author:
Lei ZHANG
;
Rong LIU
;
Juanjuan LI
;
Dixiao ZHONG
;
Mei YUE
;
Litian XUAN
- From:
Chinese Journal of Applied Clinical Pediatrics
2021;36(9):687-690
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the characteristics, diagnosis, and treatment of precursor B-cell acute lymphocytic leukemia with C- MYC rearrangement (preBLL) in children. Methods:The clinical data in 2 cases of childhood preBLL in Department of Hematology, Children′s Hospital Affiliated to Capital Institute of Pediatrics in June and August 2019 were summarized and analyzed.Results:Both cases were acute lymphoblastic leukemia with precursor B-cell immunophenotype.Hepatosplenomegaly and peripheral white blood cells were significantly increased, and the morphology of bone marrow was L3. C- MYC rearrangement was discovered by cytogenetic tests.Both children have received the treatment of the mature B-cell tumor protocol (FAB/LMB96), and early remission was developed in 1 case with TP53 gene mutation but relapsed thereafter and died finally.Another case had reached sustained complete remission after treatment. Conclusions:Children with preBLL is rare, and routine C- MYC rearrangement should be performed in children with Precursor B-cell lymphoblastic leukemia whose morphology of bone marrow was L3.Its treatment needs to be further studied, and multi-center clinical trials need to be actively conducted to analyze and summarize large numbers of cases to identify effective protocol and improve the prognosis.
