Research progress of treatment for neonatal hypoxic ischemic encephalopathy
10.3760/cma.j.cn101070-20200207-00126
- VernacularTitle:新生儿缺氧缺血性脑病治疗研究进展
- Author:
Yifan SUN
;
Cheng CAI
- From:
Chinese Journal of Applied Clinical Pediatrics
2021;36(8):631-634
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxic ischemic encephalopathy (HIE) is one of the leading causes of neonatal morbidity and mortality worldwide, and it has a series of clinical manifestations of encephalopathy.Survivors often have different degrees of neurodevelopmental impairment.In addition to supporting symptomatic treatment, hypothermia is the safest and most effective treatment for the neuroprotection and the improvement of the prognosis of neonatal HIE.However, hypothermia cannot provide complete neuroprotection and is limited by gestational age, time, and facilities and so on.Therefore, clinicians and researchers actively seek for supplements and/or alternative therapies for neonatal HIE.It was reported that stem cell transplantation has a good application prospect in the treatment of HIE.Erythropoietin and xenon and melatonin may also play neuroprotective roles in HIE.In order to provide a better theoretical basis for clinical practices, this paper reviewed the research progress of neonatal HIE treatment.
