Progress in the mechanism of phospholipase CE1 in children with primary nephrotic syndrome
10.3760/cma.j.cn101070-20191114-01132
- VernacularTitle:磷脂酶CE1在儿童原发性肾病综合征中的作用机制研究进展
- Author:
Yan ZHANG
;
Yunguang LIU
- From:
Chinese Journal of Applied Clinical Pediatrics
2021;36(5):387-390
- CountryChina
- Language:Chinese
-
Abstract:
Phospholipase CE1 (PLCE1) is a special phospholipase C isoenzyme in the phospholipase family.It is expressed in podocytes of mature glomeruli and participates in cell signal transduction through a variety of pathways, thereby promoting its growth and expression.It has been reported that the single gene mutation of PLCE1, the heterozygosis mutation with other pathogenic genes and the interaction between PLCE1 and other factors are likely to cause primary nephrotic syndrome (PNS) in children.There have been children with PLCE1 mutation-induced steroid-resistant nephrotic syndrome cured after taking calmodulin inhibitors.They bring hope to treat PNS.In this article, the expression of PLCE1, its biological function, the mechanism of PLCE1 leading to PNS in children and its treatment were reviewed.
