A report of twin brothers with pyogenic arthritis, pyoderma gangrenosum and acne syndrome

VernacularTitle:化脓性关节炎、坏疽性脓皮病和痤疮综合征孪生兄弟报道
Author: Ruqian FU ; Zhijuan KANG ; Zhihui LI
From: Chinese Journal of Applied Clinical Pediatrics 2021;36(5):382-384
CountryChina
Language:Chinese
Abstract: Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is a rare autoinflammatory bone disease, which caused by proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1) gene mutations.Due to a lack of awareness of it among clinicians, PAPA syndrome is hard to diagnose and easy to be misdiagnosed or miss-diagnosed clinically.In this paper, twin brothers with recurrent fever and joints pain were reported.They were diagnosed with suppurative arthritis by many hospitals, but after receiving the joint cavity incision operation with negative pressure drainage for several times and antibiotics treatment, their conditions were not improved.Genetic tests showed that the twin brothers had a heterozygous mutation p. E250K (NM003978.3; c.748 G>A; p.Glu250Lys) on the PSTPIP1 gene.They were finally diagnosed with PAPA syndrome and improved with glucocorticoid therapy.