Deep brain stimulation for treatment of pediatric dystonia
10.3760/cma.j.cn101070-20201231-01975
- VernacularTitle:脑深部电刺激治疗儿童肌张力障碍
- Author:
Haibo YANG
;
Qingping ZHANG
;
Yongxin WEN
;
Zhen HUANG
;
Ye WU
;
Yanling YANG
;
Cui WANG
;
Yuehua ZHANG
;
Ying HAN
;
Xinhua BAO
- From:
Chinese Journal of Applied Clinical Pediatrics
2021;36(4):279-282
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the therapeutic effect of deep brain stimulation (DBS) for dystonia.Methods:Detailed clinical information and peripheral blood of children with dystonia at Peking University First Hospital from April 2017 to July 2020 were collected.The motor scores of Burke-Fahn-Marsden Dystonia Rating Scale were recorded of the dystonia before and after the treatment of DBS.Whole-exome sequencing was performed on children with dystonia.Then the effect of DBS was evaluated.Results:A total of 32 cases of patients with dystonia treated with DBS were enrolled, including 16 males and 16 females.Twelve cases were treated with globus pallidus internus DBS, and 20 cases were treated with subthalamic nucleus DBS.Twenty cases (62.5%) with pathogenic gene mutations were detected.Pathogenic variants in PANK2 (9 cases), KMT2B(3 cases), GNAO1 (2 cases), GCDH (2 cases), PINK1(1 case), NDUFAF6(1 case), DYT27(1 case) and ADCY5(1 case) were found.The follow-up period was 1 month to 3 years and 8 months.Only 1 case had local infection due to improper home care.The postoperative improvement was 5.66%-95.92%. Conclusions:All patients have a certain degree of relief after DBS without obvious adverse reactions.DBS is an effective treatment for pediatric dystonia.
