Common etiology and pathogenesis of plastic bronchitis in children
10.3760/cma.j.cn101070-20210113-00059
- VernacularTitle:儿童塑型性支气管炎的常见病因及致病机制
- Author:
Xiaoguang HU
;
Hailin ZHANG
- From:
Chinese Journal of Applied Clinical Pediatrics
2021;36(4):244-247
- CountryChina
- Language:Chinese
-
Abstract:
Plastic bronchitis(PB) is an uncommon respiratory disease characterized by formation of casts in tracheobronchial tree.It can lead to airway obstruction, difficulty of breathing and even respiratory failure.PB in children is commonly associated with lower airway infection, cyanotic congenital heart disease and asthma or atopic diseases.It can also be found in children with sickle cell anemia, thalassemia and cystic fibrosis and so no.There are three main mechanisms for the formation of casts: airway inflammation results in mucus hypersecretion; inflammatory insults lead to necrosis and abscission of the airway epithelium, mucosal edema, and finally cause airway clearance impairment; leakage of chyle from lung lymphatic circulation into airway.But the etiology of this disease is various, pathogenesis is complex.Further research is required to elucidate the pathogenesis.
