Optimize concentrate process of loganin from Cornus officinalis by ultrafiltration-nanofiltration coupling technology

VernacularTitle:超滤-纳滤联用技术优化山萸肉中马钱苷浓缩工艺
Author: Xiaopeng CHEN ; Yun WU ; Hui YE
From: International Journal of Traditional Chinese Medicine 2021;43(4):363-368
CountryChina
Language:Chinese
Abstract: Objective:To explore the Optimize concentrate process of loganin from Cornus officinalis by ultrafiltration-nanofiltration coupling technology. Methods:Based on single factor test, nanofiltration membrane pore size, transmembrane pressure difference and pH were selected as independent variables, and the rejection of loganin was used as dependent variables. Response surface methodology of Box-Behnken Design was applied to optimize the concentrate process of loganin from Cornus officinalis. Results:Ultrafiltration can remove polysaccharides and improve the filtrability of the solution. The optimum nanofiltration concentrate conditions were nanofiltration membrane pore size 400 Da, pH 6.7 and the transmembrane pressure difference was 1.20 MPa. The average cut-off rate of loganin was (91.9 ± 1.7)%, which was close to the theoretical cut-off rate of 93.6%.Conclusion:The loganin from Cornus officinalis has been concentrated efficiently by the combination of ultrafiltration and nanofiltration. The coupling technology is stable and feasible, whinc could avoid the transformation loss of heat-sensitive ingredients.