Study on optimization of the preparation for citrus oils β-cyclodextrin microspheres inclusion compound by using the response surface methodology
10.3760/cma.j.cn115398-20200223-00186
- VernacularTitle:响应曲面法优化陈皮挥发油β-环糊精微球包合物制备工艺
- Author:
Yan ZHANG
;
Jing SONG
;
Zhen WANG
;
Xifeng ZHAI
;
Han ZHANG
;
Xi ZHANG
;
Lili WU
;
Junru LIU
- From:
International Journal of Traditional Chinese Medicine
2021;43(1):48-53
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The response surface methodology (RSM) and Box-Behnken design were adopted to optimize the preparation for citrus oils β-cyclodextrin microspheres inclusion compound. And the physical characterization and heat stability were evaluated.Methods:The best preparation technology included inverse emulsion polymerization and saturated water solution method, with volatile oil weight ratio and microspheres, microspheres and water feeding ratio, inclusion temperature as impact factors, inclusion rate as the response value, establish regression model,. We explored the orange peel naphtha beta ring paste by microscopy, infrared spectroscopy (IR), differential scanning calorimetry (DSC) and heat stability test.Results:The best preparation technology included the essential oil with beta ring paste microspheres ( V: m), the ratio of 1:10, beta ring paste small ball and the ratio of water (m: V) for 1:15, and inclusion temperature for 41 ℃. The average encapsulation efficiency and the average rate of yield under optimized conditions were 62.21% and 85.24%, respectively. The physical characterization and thermal stability tests demonstrated that the β-cyclodextrin microsphere inclusion complex of volatile oil from Citrus was successfully prepared and the physical properties were stable. Conclusion:The preparation method of citrus oils β-cyclodextrin microspheres inclusion compound by using the response surface methodology.
