Research progress on the prevention and treatment of liver cancer intervened by Traditional Chinese Medicine on related signaling pathway

VernacularTitle:中医药干预相关信号通路防治肝癌研究进展
Author: Hong SHEN ; Jiale MA ; Zhiyuan ZHAO ; Haiye LIU
From: International Journal of Traditional Chinese Medicine 2021;43(1):93-97
CountryChina
Language:Chinese
Abstract: There are many abnormal signaling pathways in the occurrence, development and microenvironment of liver cancer. The abnormal activation or inhibition of cell signaling pathway can regulate cell proliferation, apoptosis and migration, and then affect inflammation, angiogenesis and tumor migration. Experimental studies have shown that Traditional Chinese medicine (TCM) can prevent and treat hepatocellular carcinoma by intervention with the transduction of related signaling pathways, which mainly includes hedgehog signaling pathway, IL-6/STAT3 signaling pathway, NF-κB signaling pathway, PI3K/Akt/mTOR signaling pathway, MAPK signaling pathway, toll-like receptor signaling pathway and Wnt signaling pathway. At present stage, TCM has a definite effect on the prevention and treatment of liver cancer, but the specific mechanism has not been fully elucidated, and the regulation of TCM on liver cancer related signaling pathways still needs further exploration.