Bone marrow microenvironment and differentiation of leukemia cells
10.3760/cma.j.cn371439-20200619-00038
- VernacularTitle:骨髓微环境与白血病细胞分化
- Author:
Xi CHEN
;
Dan MU
;
Qin YAN
;
Wenjun LIU
- From:
Journal of International Oncology
2021;48(3):189-192
- CountryChina
- Language:Chinese
-
Abstract:
Bone marrow microenvironment (BMM) is the environment on which leukemia cells depend. It contains stem cells, bone marrow stromal cells, and abundant cytokines, which can regulate the differentiation and proliferation of leukemia cells. The regulation of BMM on the differentiation of leukemia cells is a complex process that can act on different targets and signaling pathways. It mainly includes hypoxia-inducible factor, integrins, Notch, and Wnt/β-catenin signal pathways. The study of relationship between BMM and leukemia cell differentiation can help to find pathways and targets that induce leukemia differentiation which will find new directions for the treatment of leukemia.
