Common immune-related adverse reactions of immune checkpoint inhibitors and their management
10.3760/cma.j.cn371439-20200828-00020
- VernacularTitle:免疫检查点抑制剂常见免疫相关不良反应及其管理
- Author:
Hui LI
;
Yu YANG
- From:
Journal of International Oncology
2021;48(2):105-108
- CountryChina
- Language:Chinese
-
Abstract:
At present, immune checkpoint inhibitors (ICIs) are widely used in clinical, and the common adverse reactions include adverse reactions of skin, gastrointestinal tract, endocrine and liver. Adverse reactions to the lungs and heart are relatively rare, but can be fatal. Systemic steroid therapy is the main treatment for immune related adverse events (irAEs). If there is no response to steroid therapy, an immunomodulator may be considered. Understanding the incidence, pathogenesis, common types and treatment strategies of irAEs can provide theoretical basis for the safe application of ICIs in clinical practice.
