IGF2BP1 and cancer
10.3760/cma.j.cn371439-20200923-00017
- VernacularTitle:IGF2BP1与肿瘤
- Author:
Zhefeng HE
;
Tiemin PEI
;
Qinghui MENG
- From:
Journal of International Oncology
2021;48(2):92-95
- CountryChina
- Language:Chinese
-
Abstract:
The insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is a key regulator of mRNA metabolism and transport during development. Recent studies indicate that IGF2BP1 is aberrantly expressed in liver cancer, lung cancer, colon cancer, ovarion cancer, breast cancer, etc.. IGF2BP1 expression is found to promote tumor cell proliferation, migration, invasion, and correlate with poor prognosis. Further understanding of the mechanism of IGF2BP1 in malignancy may provide new targeted therapy strategies.
