Role of antibiotics in tumor development and immunotherapy

VernacularTitle:抗生素在肿瘤发生发展及免疫治疗中的作用
Author: Mengxue YANG ; Man YUAN ; Jiandong TONG ; Xuebing YAN
From: Journal of International Oncology 2021;48(1):48-51
CountryChina
Language:Chinese
Abstract: In recent years, immunotherapy with immune checkpoint inhibitor (ICI) as the representative drug has become an important treatment method for advanced malignant tumors. Preclinical studies have found that disorders of the gut microbiota can reduce the clinical benefit of patients treated with ICI. The latest data indicate that antibiotics may further affect the occurrence and development of tumors and the efficacy of immunotherapy by changing the abundance and composition of intestinal microbiota. To sum up the role of anti-biotics in the immunotherapy of advanced malignant tumor may provide a new idea for the optimization of treatment strategies for patients with advanced cancer.