Research advances of Mfn2 in tumor
10.3760/cma.j.cn371439-20200212-00008
- VernacularTitle:Mfn2在肿瘤中的研究进展
- Author:
Mengyu WEI
;
Li MA
- From:
Journal of International Oncology
2021;48(1):45-47
- CountryChina
- Language:Chinese
-
Abstract:
Mitofusin 2 (Mfn2) plays an important role in the process of mitochondrial fusion, and is involved in regulating mitochondrial function and morphological changes. Studies have found that Mfn2 has a tumor suppressor effect in a variety of malignant tumors and their cell lines, including cervical cancer, hepatocellular cancer, pancreatic cancer, breast cancer, and bladder cancer. The difference in the expression of Mfn2 in malignant tumor tissues suggests that Mfn2 may play an important role in the proliferation, apoptosis, invasion and migration of malignant tumor cells. As a cancer-related gene, Mfn2 provides new ideas for gene therapy of malignant tumors.
