Research progress of Kruppel-like factor family in malignant tumors

VernacularTitle:Kruppel样因子家族在恶性肿瘤中的研究进展
Author: Zhi ZHENG ; Yixuan DING ; Wentong MEI ; Yulin GUO ; Yuanxu QU ; Jiongdi LU ; Shuang LIU ; Haichen SUN ; Feng CAO ; Fei LI
From: International Journal of Surgery 2021;48(4):264-268
CountryChina
Language:Chinese
Abstract: Malignant tumors usually have no obvious clinical symptoms in the early stage. Most patients are already in the advanced stage when they are diagnosed. Some patients have lost the opportunity for operation, resulting in poor prognosis. Therefore, how to find the best therapeutic target for such patients and improve the prognosis of patients has gradually become the focus of scholar′s attention. Recently, Kruppel-like factor (KLF) is a transcriptional regulator that can bind to the target DNA, and its family plays an important role in the occurrence and development of malignant tumors. It has also been confirmed that the KLF family affects the proliferation, differentiation and migration of tumor cells, but the specific mechanism is still not fully elucidate. Consequently, in order to further explored the effect of the KLF family on tumors, this study intends to briefly review the roles and regulatory mechanisms of the KLF family in the cell proliferation, differentiation and migration of malignant tumors, hoping to provide new target for the biological treatment of tumors.