Application of antibody inducers in solid organ transplantation

VernacularTitle:抗体类免疫诱导剂在实体器官移植中的应用现状
Author: Zhangyong REN ; Shaocheng LYU ; Qiang HE
From: International Journal of Surgery 2021;48(1):45-50
CountryChina
Language:Chinese
Abstract: Organ transplantation is the first effective treatment for end-stage organ failure. However, early acute rejection after organ transplantation is often an important factor leading to transplantation failure. In order to reduce the incidence of rejection after organ transplantation, it is often necessary to use potent immunosuppressants to induce the immune system of recipients before or during transplantation. As a common method of covering immunosuppressive therapy in the early stage of organ transplantation, antibody immunoinducers can significantly reduce the occurrence of early acute rejection after organ transplantation, and delay or reduce the application of calcineurin inhibitor drugs, which is conducive to protecting renal function, promoting graft function recovery and long-term survival of recipients. This article reviews the application of antibody inducers in solid organ transplantation.