Research progress of vascularized tissue engineered trachea preparated by 3D bioprinting

VernacularTitle:3D生物打印构建组织工程气管血管化的研究进展
Author: Fei SUN ; Yi LU ; Hongcan SHI
From: International Journal of Surgery 2021;48(1):40-44
CountryChina
Language:Chinese
Abstract: Tissue engineering can provide alternatives to current methods for tracheal reconstruction. Functional and perfusable vascular network formation is critical to ensure the long-term survival and functionality of engineered tissues after their transplantation. The greatest challenges in tracheal replacement are restoration of blood supply rapidly to support cell metabolism and promote tissue healing and regeneration. The traditional methods of tracheal transplantation vascularization are traumatic and requires secondary operation, which don′t meet the current ethical requirements of rapid rehabilitation surgery. The integrated printing of cells, biomaterials and growth factors through 3D bio-printing technology is expected to become a new development direction of vascular tissue engineering trachea.