Research progress in autophagy and tumor angiogenesis
10.3760/cma.j.cn121382-20200810-00110
- VernacularTitle:自噬与肿瘤血管生成的研究进展
- Author:
Xingfen WANG
;
Rui LIANG
;
Xianglian ZHANG
;
Liping XU
- From:
International Journal of Biomedical Engineering
2021;44(1):55-59
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a special cellular process, which can participate in regulating cell survival, growth, differentiation and homeostasis maintenance by transporting damaged organelles and macromolecular substances to lysosomes for degradation. Autophagy plays a very important role in all aspects of life process. Research results show that autophagy plays an important role in tumor occurrence, development and metastasis. The synergistic effect of autophagy and vascular endothelial growth factor promotes tumor angiogenesis and cell repair, and may play an important role in the development of tumor resistance to anti-vascular drug therapy. Targeted therapy with autophagy as the target may be a new direction for anti-tumor molecular targeted therapy in the future, aiming to provide multi-target collaborative therapy to benefit patients.
