Research progress of Piezo mechanosensitive ion channels in bone and joint tissues
10.3760/cma.j.cn121382-20200914-00109
- VernacularTitle:Piezo机械敏感性离子通道在骨关节组织中的研究进展
- Author:
Chao ZHANG
;
Ping WANG
;
Aifeng LIU
;
Juntao ZHANG
;
Yuandong LI
- From:
International Journal of Biomedical Engineering
2021;44(1):50-54
- CountryChina
- Language:Chinese
-
Abstract:
Mechanosensitive ion channels are mechanoreceptors that convert mechanical stimulation on the cell surface into intracellular electrical signal or chemical signal. In recent years, Piezo protein as a mechanically activated cation channel in eukaryotes has gradually become a research hotspot. Piezo1 and Piezo2 proteins are expressed in different organs and tissues of mammals, and tissues such as bones and joints are directly related to mechanical conduction. The intracellular effects caused by the conduction of mechanical force play a very important role in the treatment and prevention of orthopedic diseases. In this paper, the researches on Piezo protein mechanically activated cation channels in bone tissue, cartilage tissue, bone marrow tissue, intervertebral disc tissue and orthopedic diseases were reviewed.
