Effect of leucine-rich α2-glycoprotein-1 on ischemic stroke by regulating transforming growth factor β signaling pathway
10.3760/cma.j.issn.1673-4165.2021.01.010
- VernacularTitle:富亮氨酸ɑ2-糖蛋白-1调节转化生长因子-β信号通路在缺血性卒中中的作用
- Author:
Meng ZHANG
;
Xudong PAN
;
Aijun MA
- From:
International Journal of Cerebrovascular Diseases
2021;29(1):53-57
- CountryChina
- Language:Chinese
-
Abstract:
As one of the leucine-rich repeat protein family members, leucine-rich α-2 glycoprotein 1 (LRG1) affects many diseases by transforming growth factor (TGF)-β signaling pathway, and is closely associated with angiogenesis, endothelial cell apoptosis and autophagy, inflammatory reaction and blood-brain barrier damage after cerebral ischemia. It is expected to become a new marker and therapeutic target of ischemic stroke. However, at present, there are few studies on investigating the relationship between LRG1 and ischemic stroke, and the understanding of its molecular mechanism is not yet complete, resulting in controversy about the role of LRG1 in ischemic stroke. Therefore, this article reviews the research progress of LRG1-TGF-β signaling pathway and ischemic stroke, hoping to provide new ideas for the early diagnosis, prevention and treatment of ischemic stroke.
