Regulation of non-immunomodulatory interaction between pertussis toxin and host cells
10.3760/cma.j.issn.1673-4408.2021.05.011
- VernacularTitle:百日咳毒素和宿主细胞非免疫调节相互作用的研究进展
- Author:
Dan YU
;
Kaihu YAO
- From:
International Journal of Pediatrics
2021;48(5):331-334
- CountryChina
- Language:Chinese
-
Abstract:
Pertussis toxin(PTx), an important toxin that produced by Bordetella pertussis, is an important pathogenic factor in the pathogenesis of whooping cough.The previous studies have showed that PTx interacting proteins vary distinctly in size, ranging from the 43 kD surface protein of human lymphocyte to the 200 kD surface protein of insulin secreting cells.PTx has been shown to interact with N-linked oligosaccharides on the surface of host cells, sialoglycoprotein-like factors, glycoproteins such as haptoglobin, fetuin, G D1a glycolipids.Especially, the interaction of PTx with its receptor Gi protein can result in increased intracellular cAMP level, which will lead to multiple physiological responses.However, the current limited understanding of other PTx modified substrates and interacting proteins in cells has seriously hindered our understanding on the mechanism that PTx regulates other signaling pathways and physiological functions of the host.
