Stem cells in the pathogenesis and treatment of Kawasaki disease
10.3760/cma.j.issn.1673-4408.2021.05.003
- VernacularTitle:干细胞在川崎病发病机制与治疗中的作用
- Author:
Xin GUO
;
Mingguo XU
- From:
International Journal of Pediatrics
2021;48(5):299-301
- CountryChina
- Language:Chinese
-
Abstract:
Kawasaki disease is a systemic inflammatory disease of small and medium vessels in children under 5 years of age, which is also one of the most common causes of acquired heart disease in children.Stem cells are a kind of multipotential cells with the ability of self-renewal, self-replication and multi-differentiation.They are important biomaterials in modern regenerative medicine and tissue engineering.So far, substantial studies have found that stem cells such as endothelial progenitor cells, induced multifunctional stem cells, adipose-derived stem cells and so on are involved in the regulation of the pathogenesis of Kawasaki disease and play an important role in anti-inflammation and protection of the vascular endothelial cell damage.The potential of stem cells is gradually being developed and applied to the diagnosis and treatment of Kawasaki disease.However, the pathogenesis and treatment of stem cells in Kawasaki disease are not fully understood, and more basic and clinical trials are still needed.
