Relationship between gut microbiota and Kawasaki disease
10.3760/cma.j.issn.1673-4408.2021.05.001
- VernacularTitle:肠道菌群与川崎病关系研究进展
- Author:
Hui LIU
;
Shan LU
- From:
International Journal of Pediatrics
2021;48(5):291-294
- CountryChina
- Language:Chinese
-
Abstract:
Kawasaki disease is a disease based on systemic vasculitis, which has become the most common disease in children with acquired heart disease, but its etiology and pathogenesis remain unclear.The homeostasis of the gut microbiota plays an important role in the maturation of the body′s immune system and immune regulation.The disorder of the gut microbiota is involved in a variety of inflammatory and immune diseases in children.Studies have found that there are changes in the composition of gut microbiota in children with Kawasaki disease.Gut microbiota disorders are related to the occurrence and development of Kawasaki disease, with the immune system function affected.Various mechanisms such as intestinal mucosal barrier dysfunction, immune inflammation, oxidative stress and metabolite effects promote the pathogenesis of Kawasaki disease.This article reviews the research on the relationship between gut microbiota and Kawasaki disease.
