The role of pericytes in scar formation of central nervous system
10.3760/cma.j.issn.1673-4408.2021.04.009
- VernacularTitle:周细胞在中枢神经系统瘢痕形成中的作用
- Author:
Danrui DING
;
Qiong WU
;
Qiong WU
;
Hua WANG
- From:
International Journal of Pediatrics
2021;48(4):253-256
- CountryChina
- Language:Chinese
-
Abstract:
Scar formation, also known as tissue fibrosis, is a common response when most organs of the body get pathological damage.The cell populations involved are as follows: circulating fibroblasts from bone marrow, endothelial cells, resident fibroblasts, epithelial cells, and perivascular cells(pericytes).Pericytes are a kind of vascular wall cells, surrounding endothelial cells on the side of basement membrane in the microvascular system.It plays an important role in angiogenesis, maintaining the blood-brain barrier, regulating function of capillary blood, mediating the entry of immune cells into the brain, fibrosis response and so on.There is accumulating evidence suggests that pericytes are involved in the scar formation of central nervous system.This article reviews the scar formation process of central nervous system diseases such as spinal cord injury, epilepsy and traumatic brain injury, with emphasis on the role of pericytes in scar formation of central nervous system.On this basis, the perspective of pericytes involved in the regulation of scar formation is given.
